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DNA Replication and Human Disease

DNA Replication and Human Disease PDF Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :

Book Description

DNA Replication and Human Disease

DNA Replication and Human Disease PDF Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :

Book Description


DNA Repair and Human Disease

DNA Repair and Human Disease PDF Author: Adayabalam Balajee
Publisher: Springer Science & Business Media
ISBN: 0387368027
Category : Medical
Languages : en
Pages : 150

Book Description
DNA Repair and Human Disease highlights the molecular complexities of a few well-known human hereditary disorders that arise due to perturbations in the fidelity of diverse DNA repair machineries.

Viruses and Human Disease

Viruses and Human Disease PDF Author: Ellen G. Strauss
Publisher: Elsevier
ISBN: 9780080553160
Category : Science
Languages : en
Pages : 480

Book Description
Completely revised and updated, the new edition of this groundbreaking text integrates basic virology with pathophysiological conditions to examine the connection between virology and human disease. Most virology textbooks focus on the molecular biology involved without adequate reference to physiology. This text focuses on viruses that infect humans, domestic animals and vertebrates and is based on extensive course notes from James Strauss’ virology class at the California Institute of Technology taught for over 30 years. Expertly depicting in color the molecular structure and replication of each virus, it provides an excellent overview for students and professionals interested in viruses as agents of human disease. Includes over 30% new material - virtually all of the figures and tables have been redrawn to include the latest information and the text has been extensively rewritten to include the most up-to-date information Includes a new chapter on emerging and reemerging viral diseases such as avian flu, SARS, the spread of West Nile virus across America, and the continuing spread of Nipah virus in Southeast Asia Further reading sections at the end of each chapter make it easy find key references World maps depicting the current distribution of existing and newly emerging viruses are also incorporated into the text

Genome Integrity

Genome Integrity PDF Author: Dirk-Henner Lankenau
Publisher: Springer Science & Business Media
ISBN: 3540375317
Category : Science
Languages : en
Pages : 496

Book Description
This is the first book to give a full overview on genome integrity in different species. From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. Written by an international panel of experts, the book addresses the connection between genome integrity and human disease.

The Mechanisms of DNA Replication

The Mechanisms of DNA Replication PDF Author: David Stuart
Publisher: IntechOpen
ISBN: 9789535109914
Category : Medical
Languages : en
Pages : 500

Book Description
DNA replication is a fundamental part of the life cycle of all organisms. Not surprisingly many aspects of this process display profound conservation across organisms in all domains of life. The chapters in this volume outline and review the current state of knowledge on several key aspects of the DNA replication process. This is a critical process in both normal growth and development and in relation to a broad variety of pathological conditions including cancer. The reader will be provided with new insights into the initiation, regulation, and progression of DNA replication as well as a collection of thought provoking questions and summaries to direct future investigations.

The Mechanisms of DNA Replication

The Mechanisms of DNA Replication PDF Author: David Stuart
Publisher: IntechOpen
ISBN: 9789535109914
Category : Medical
Languages : en
Pages : 500

Book Description
DNA replication is a fundamental part of the life cycle of all organisms. Not surprisingly many aspects of this process display profound conservation across organisms in all domains of life. The chapters in this volume outline and review the current state of knowledge on several key aspects of the DNA replication process. This is a critical process in both normal growth and development and in relation to a broad variety of pathological conditions including cancer. The reader will be provided with new insights into the initiation, regulation, and progression of DNA replication as well as a collection of thought provoking questions and summaries to direct future investigations.

DNA Damage, Genome Stability and Human Disease

DNA Damage, Genome Stability and Human Disease PDF Author: Yuejin Hua
Publisher: Frontiers Media SA
ISBN: 288974194X
Category : Science
Languages : en
Pages :

Book Description


Replication Timing: Evolution, Nuclear Organization and Relevance for Human Disease

Replication Timing: Evolution, Nuclear Organization and Relevance for Human Disease PDF Author: Megan Lynne Wright
Publisher:
ISBN: 9789533075938
Category :
Languages : en
Pages :

Book Description


Mutagenesis Associated with DNA Secondary Structure: Consequences for Human Disease

Mutagenesis Associated with DNA Secondary Structure: Consequences for Human Disease PDF Author: Vera Issam Hashem
Publisher:
ISBN:
Category :
Languages : en
Pages : 476

Book Description
ABSTRACT: Maintenance of DNA integrity is essential for survival of the organism. Many factors can compromise that integrity including both the DNA sequence itself and defective metabolic processes. One third of the human genome is composed of DNA repeats, including mono, di-, tri-, and tetranucleotide repeats, as well as direct and inverted repeats. Palindromic DNA is an intrinsic part of many genomes, and its ability to adopt alternative DNA structures makes it prone to genomic changes. These sequences can inherently form secondary structures that promote instability, which can lead to disease. Normally, a cell contains essential functions such as DNA repair and recombinational mechanisms that maintain DNA integrity, and thus, the functionality of the genome. Certain factors affect this integrity. Environmental and therapeutic agents can affect the stability of repeated DNA, as can mutations in certain genes involved in replication, repair and recombination. Understanding the effect that secondary structures may have on DNA integrity during DNA replication and what factors may influence their mutagenic potential are imperative for understanding disease mechanisms and for developing possible treatments. I investigated the effects of several secondary structure forming sequences on mutagenesis and explored factors that lead to an increase in mutagenesis. We found an effect of certain proteins involved in replication, DNA repair and recombination, including RecA, UvrA, UvrB, SbcC, MutS and LexA, on instability associated with trinucleotide repeat sequences. We further investigated the effect of certain genotoxicants and anti-cancer agents on the rate of deletion of trinucleotide repeat sequences. Results from these experiments suggest a therapeutic benefit of certain anticancer agents in the treatment of trinucleotide repeat expansion diseases.

DNA Repair and Replication

DNA Repair and Replication PDF Author: Roger J. A. Grand
Publisher: Garland Science
ISBN: 0429876548
Category : Science
Languages : en
Pages : 368

Book Description
DNA Repair and Replication brings together contributions from active researchers. The first part of this book covers most aspects of the DNA damage response, emphasizing the relationship to replication stress. The second part concentrates on the relevance of this to human disease, with particular focus on both the causes and treatments which make use of DNA Damage Repair (DDR) pathways. Key Selling Features: Chapters written by leading researchers Includes description of replication processes, causes of damage, and methods of repair